Objective: Sclerosis is a neurodegenerative disease that is important in measuring and evaluating the cognitive abilities of its patients. Therefore, the diagnostic dimensions of functional differences in cognitive abilities of subgroups of this disease are important. 
Methods: The research was done with post-event design. The sample consisted of 60 subjects from different groups of patients with sclerosis in Tehran. The research tool was a cognitive test of Montreal. The research hypotheses were analyzed by MANOVA test.
Results: The findings showed that there are some differences between the different subgroups of sclerosis patients and healthy people. There was no difference in memory function between the subgroups of sclerosis. Healthy individuals differed in working memory (4.43 vs. 1.83 to 2.23), cognitive function (27.7 vs. 19 to 21.9), attention and centralization (5.3 vs. 3.9 to 4.8), and visual spatial perception (4.6 vs. 2 to 2.9) with patients.
Conclusion: The findings indicate that there are some differences in the cognitive functions of different groups of sclerosis. The results emphasize the role of cognitive rehabilitation for patients.