Objective: Multiple sclerosis (MS) has several physical, psychological, and psychiatric symptoms. Regarding the psychological impact of MS on aspects of life, this study sought to examine the effect of group quality of life therapy on depression and anxiety in these patients.

Methods: Two groups of 15 matched patients with MS were randomly assigned to experimental and control groups after completing the Cattell anxiety scale and Beck depression questionnaire (short form). Then, the quality of life group therapy was carried out on the experimental group. At the end, both groups participated in the posttest assessments.

Results: Analysis of covariance showed that the implemented intervention helped reduce the anxiety and depression in patients with MS (F=4.46, P=0.04 F=41.4, P=0.001, respectively).

Conclusion: Quality of life group therapy can help reduce anxiety and depression in patients with MS by improving their life satisfaction, meaningfulness, and sense of worthiness.