en رويكرد شناختي رفتاري Cognitive behavioral پژوهشي Original Research Article <strong>Objective</strong>: Given the importance of COVID-19 consequences and students&rsquo; health, this study aimed to predict the fear of COVID-19 based on spiritual well-being and self-efficacy among Iranian university students by focusing on the mediating role of mindfulness.<br> <strong>Methods</strong>: This study was a descriptive correlational study. An online sampling method was used, and the sample included 396 university students in Tehran City, Iran. Mindful Attention Awareness Scale (MAAS), general self-efficacy scale, fear of COVID-19 scale, and Paloutzian and Ellison&rsquo;s spiritual well-being scale were used for data collection. An independent t test, the Pearson correlation, and the regression test were used to analyze the obtained data.<br> <strong>Results</strong>: The results show that the overall effects of religious well-being (&beta;=-0.192, P=0.001), existential well-being (&beta;=-0.227, P=0.001), and self-efficacy (&beta;=-0.093, P=0.013) were significant. The indirect effects of religious well-being (&beta;=-0.026, P=0.001), existential well-being (&beta;=-0.013, P=0.016), and self-efficacy (&beta;=-0.04, P=0.001) were significant, too. The direct effects of religious well-being (&beta;=-0.253,P=0.001), existential well-being (&beta;=-0.205, P=0.016), and self-efficacy (&beta;=-0.133, P=0.013) were significant, as well.<br> <strong>Conclusion</strong>: Spiritual well-being, self-efficacy, and mindfulness are associated with a reduction in perceived fear of COVID 19 in Iranian students, and mindfulness has a role in these relationships.&nbsp; <div><div></div></div> Fear of COVID-19, Spiritual well-being, Self-efficacy, Student, Mindfulness 1 10 http://jpcp.uswr.ac.ir/browse.php?a_code=A-10-288-6&slc_lang=en&sid=1 Roghieh Nooripour r.noori@alzahra.ac.ir 0000-0002-5677-0894 Yes Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran. Simin Hosseinian hosseinian@alzahra.ac.ir 0000-0003-1852-3953 No Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran. Maryam Sobhaninia sar.nour66@gmail.com No Department of Counseling, Faculty of Education and Psychology, Alzahra University, Tehran, Iran. Nikzad Ghanbari nik.gh.pirkashan@gmail.com 0000-0002-9012-8600 No Department of Clinical Psychology, Faculty of Education and Psychology, Shahid Beheshti University, Tehran, Iran. Saba Hassanvandi nimsada.2020@gmail.com No Department of Psychology, Faculty of Humanistic Sciences, Khorramabad Branch, Islamic Azad University, Khorramabad, Iran. Hossein Ilanloo hosseinelanloo@gmail.com 0000-0003-0100-3257 No Department of Psychology, Faculty of Education and Psychology, Kharazmi University, Tehran, Iran. Keyvan Kakabraee simi.911818@gmail.com 0000-0002-9970-4854 No Department of Psychology, Faculty of Humanistic Sciences, Kermanshah Branch, Islamic Azad University, Kermanshah, Iran.