en توانبخشي Rehabilitation پژوهشي Original Research Article <div style="text-align: justify;"><strong>Objective</strong>: This study was done to investigate the relationship between existential anxiety and demoralization syndrome in predicting psychological well-being in patients with cancer.&nbsp;<br> <strong>Methods</strong>: This correlational study was done on 57 patients with cancer (skin, breast, and stomach) aged 20-40 years, referring to hospitals in Ardabil selected by purposive sampling. The selected individuals completed the existential anxiety, demoralization syndrome, and psychological well-being questionnaires. To analyze the data, the stepwise regression analysis was used.<br> <strong>Results</strong>: The results showed a significant negative correlation between the existential anxiety and predicting psychological well-being in patients with cancer (P<0.01) and also a significant negative correlation between demoralization syndrome and prediction of depression in patients with cancer (P<0.01).<br> <strong>Conclusion</strong>: According to the results of this study, people facing life-threatening illnesses, such as cancer experience existential concerns, such as death anxiety, uncertainty, absurdity, and loneliness and the aim of psychotherapy and counseling interventions in these people is to create a supportive atmosphere that helps these patients to accept the disease, and consequently improve their mental health.</div> Existential anxiety, Demoralization syndrome, Psychological well-being, Cancer 175 182 http://jpcp.uswr.ac.ir/browse.php?a_code=A-10-515-1&slc_lang=en&sid=1 Elyas Nikoy Kouhpas elyas.nikoy72@gmail.com 0000-0003-0855-4668 No Department of Counseling, School of Behavioral Sciences, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Zeinab Karimi zeinabkarimi12@yahoo.com 0000-0003-2951-2475 No Department of Counseling, Faculty of Behavioral Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran. Bahman Rahmani mehdirahmany22@gmail.com 0000-0003-2509-0578 No Department of Counseling, Faculty of Behavioral Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran. Fatemah Shoaee shoaeef@yahoo.com 0000-0003-2497-3774 Yes Department of Counseling, Faculty of Behavioral Sciences, Shahid Rajaee Teacher Training University, Tehran, Iran.