en سوء مصرف و وابستگي به مواد Substance abuse and dependence پژوهشي Original Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Objective</strong>: Although the relationship between childhood trauma and the presence of substance use tendencies (SUT) has been proven worldwide, little Iranian-based evidence exists. Nonetheless, this study is the first to empirically test such a correlation in a sample population of Iranian university students with post-traumatic stress disorder (PTSD) symptoms, emotion dysregulation, and impulsivity serving as mediators of this relationship.<br> <strong>Methods</strong>: A group of 766 Iranian university students (33.4% male and 66.6 % female; mean age=24.89) was asked to complete the validated questionnaires, which featured the childhood trauma questionnaire-short form (CTQ-SF), difficulties in emotion regulation scale (DERS), addiction potential scale (APS), short UPPS-P impulsive behavior scale (SUPPS-P), and posttraumatic stress disorder checklist for DSM-5 (PCL-5). Analyses were performed using structural equation modeling (SEM).<br> <strong>Results</strong>: Childhood trauma was strongly related to greater impulsivity, emotional dysregulation, PTSD symptoms, and SUT. These psychological factors significantly mediate childhood trauma in SUT.&nbsp;<br> <strong>Conclusion</strong>: These results underscore the necessity of developing specific interventions that would focus on impulsivity, emotional dysregulation, and PTSD symptoms, to decrease the risk of SUT among Iranian university students with a history of childhood trauma.</span></span></span></div> Adverse childhood experiences (ACEs), Substance use, Impulsive behavior, Emotion regulation, Post-traumatic stress disorder (PTSD) 287 298 http://jpcp.uswr.ac.ir/browse.php?a_code=A-10-877-2&slc_lang=en&sid=1 Mohammad Hossein Abdolloahi m.h.abdollahi98@gmail.com 0009-0007-2255-8012 No Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran. Shahram Mohammadkhani mohammadkhani@khu.ac.ir 0000-0001-7541-6412 Yes Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran. Robabeh Noury r.noury@khu.ac.ir 0000-0003-3414-3539 No Department of Clinical Psychology, Faculty of Psychology and Education, Kharazmi University, Tehran, Iran.