en روانپزشكي Psychiatry پژوهشي Original Research Article <div style="text-align: justify;"><span style="font-size:14px;"><span style="font-family:Tahoma;"><span style="line-height:2;"><strong>Objective</strong>: Multiple sclerosis (MS) is an autoimmune disease of the central nervous system. Psychological manifestations, such as depression, anxiety, and stress are common in patients with MS. Social support is involved in the well-being of patients with MS. This study aims to assess the relationship between perceived social support with depression, anxiety, and stress in patients with MS.<br> <strong>Methods</strong>: This descriptive correlation study was conducted on 240 patients with MS who were referred to the MS Center of Isfahan Province, Iran. Three questionnaires of the depression anxiety stress scale 21 (DASS-21), social support, and demographic questionnaires were used to collect data. Data were analyzed with SPSS software, version 20 using descriptive and analytical statistics (independent t-test, one-way analysis of variance (ANOVA), and Pearson correlation).&nbsp;<br> <strong>Results</strong>: In the current study, the mean perceived social support was 27.35&plusmn;9.06. The mean depression, anxiety, and stress were 14.96&plusmn;5.42, 13.92&plusmn;5.88, and 15.39&plusmn;4.82, respectively. In addition, an inverse correlation was observed between social support with depression, and anxiety (P<0.01). Moreover, no significant relationship was observed between social support and stress (P=0.21). Social support was a significant negative predictor that accounted for 11.8% of the variance in depression (R2=0.118, P<0.001) and 3.4% of the variance in anxiety (R2=0.034, P=0.002).<br> <strong>Conclusion</strong>: According to the results of this study, social support of patients with MS can be one of the effective suggestions to decrease depression and anxiety.&nbsp;</span></span></span><br> <br> <strong>Coresponding author:&nbsp;</strong>Samaneh Yazdani,&nbsp;E-mail: <em>Samanehyazdani1371@gmail.com</em><br> <u>You can also search for this author in:</u>&nbsp;<a href="https://scholar.google.com/citations?hl=en&user=qfzLC1wAAAAJ">Google scholar</a></div> Anxiety, Depression, Multiple sclerosis, Stress, Social support 319 328 http://jpcp.uswr.ac.ir/browse.php?a_code=A-10-885-1&slc_lang=en&sid=1 Maasoumeh Barkhordari-Sharifabad Barkhordary_m@yahoo.com 0000-0002-9832-2280 No Department of Nursing, Faculty of Medical Sciences, Yazd Branch, Islamic Azad University, Yazd, Iran. Morteza Zangeneh Soroush Morteza.bme@gmail.com 0000-0001-7117-564x No Department of Biomedical Engineering, Engineering Research Center in Medicine and Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran. Samaneh Yazdani Samanehyazdani1371@gmail.com 0000-0001-5520-7357 Yes Community Health Research Center, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.