en رويكرد شناختي رفتاري Cognitive behavioral پژوهشي Original Research Article <p style="text-align: justify;"><strong>Objective:</strong> Sexual dysfunction is frequently reported as a side effect of many antidepressant medications. As a result, for those depressed patients to whom sexual desire is important, psychological treatment may be a better intervention. Thus, the present study aimed to determine the possible changes in sexual desire following psychological treatments in depression, when focus of therapy is not on sexual function.<br> <strong>Methods:</strong> This is a quasi-experimental study, which was conducted in Tehran, Iran. A total of 281 depressed patients in the remission phase underwent psychological treatments, either cognitive behavioral therapy (CBT, n=131) or mindfulness-based cognitive therapy (MBCT, n=150). The therapy did not focus on any aspect of sexual function. Using a single item measure before and after treatment, sexual desire of the patients was categorized into intact, mild, moderate, or severe decline. A total of 255 participants completed the study questionnaires and were randomly assigned to CBT (122) and MBCT groups (133). Before therapy, 128(50.2%) participants were categorized in intact sexual desire group, 73(28.6%) in mild sexual desire dysfunction group, 40(15.7%) in moderate sexual desire dysfunction group, and 14(5.5%) in severe sexual desire dysfunction group. Logistic regression was used for analyzing the data by SPSS-16.<br> <strong>Results:</strong> Low sexual desire in depression remission was predicted by age (P<0.001, OR=0.21, CI=0.01&ndash;0.03), presence of comorbid anxiety disorder (P<0.04, OR=-0.13, CI=-0.46&ndash;0.02), and global assessment of functioning (GAF) (P<0.001, OR=-0.23, CI=-0.03&ndash;0.01). Clinical improvement in sexual desire was predicted by the type of intervention (P=0.023, OR=0.351, CI=0.142&ndash;0.869) and GAF (P=0.003, OR=0.927, CI=0.881&ndash;0.975).<br> <strong>Conclusion:</strong> CBT might be superior to MBCT in improving sexual desire in patients with depression. Further studies using validated sexual function questionnaires are necessary.</p> Depression, Sexual desire, Cognitive behavioral therapy, Mindfulness-based cognitive therapy 211 220 http://jpcp.uswr.ac.ir/browse.php?a_code=A-10-427-2&slc_lang=en&sid=1 Parvaneh Mohammadkhani No Social Welfare Management Research Center, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran. Keith S. Dobson No University of Calgery, Alberta, Canada. Mohammad Reza Tamannaeifar No Department of Psychology, Faculty of Humanities, University of Kashan, Kashan, Iran. Imaneh Abasi emaneabassi@yahoo.com Yes Department of Clinical Psychology, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran. Hedieh Azadmehr No Community Research Foundation, San Diego, California.