Objective: This study was conducted to investigate the association between Islamic lifestyle and addiction potential among adolescents residing in Eslamshahr City, Iran.
Methods: This was a cross sectional study. The statistical population consisted of all students attending public high schools during 2012-2013 academic year in Eslamshahr City. The sample size was 211, who were selected through multi-stage cluster sampling method. The Islamic lifestyle and addiction potential questionnaires were used to collect data. 
Results: The Pearson correlation coefficient showed significant and inverse associations between the components of Islamic lifestyle and addiction potential, except for ‘timeliness’ (P < 0.01).
Conclusion: Those adopting an Islamic lifestyle are less prone to substance abuse.