Methods: The purpose of this study was to compare cognitive deficits in siblings of the patients with schizophrenia and control group. A total of 35 unaffected siblings of patients with schizophrenia were selected from the relatives of the patients referred to Shoosh clinic and 35 matched healthy controls were selected from the staff of the same clinic. This sample was chosen accessible. Then, the subjects completed Verbal Paired Association Test, Logical Memory Test, Wechsler Memory Scale-Revised, and N-back working memory Test. Data were analyzed by Chi-square, t test, and Multivariate analyses of variance (MANOVA). Statistical analysis was performed using SPSS version 20.