Methods: This study is a descriptive–correlational research. Multi-stage cluster sampling was used to select 230 high-school students in Kermanshah City. To measure the variables, Zuckerman’s Sensation Seeking Scale Form V, Coping Strategies Questionnaire (Billings and Moos), and the Addiction Potential Scale (Weed and Butcher) were used. Data were analyzed using Pearson correlation and multiple regression analysis. 

Results: There was a significant relationship between sensation-seeking and drug addiction potential among the students. Moreover, coping strategies could predict drug abuse potential, and emotion-focused coping was the most powerful predicting variable. 

Conclusion: According to our results, people with a higher level of sensation-seeking and those who use emotion-focused coping strategies are more prone to substance abuse.